Ontology highlight
ABSTRACT:
SUBMITTER: Andresen V
PROVIDER: S-EPMC3156045 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Andresen Vibeke V Pise-Masison Cynthia A CA Sinha-Datta Uma U Bellon Marcia M Valeri Valerio V Washington Parks Robyn R Cecchinato Valentina V Fukumoto Risaku R Nicot Christophe C Franchini Genoveffa G
Blood 20110615 6
Disease development in human T-cell leukemia virus type 1 (HTLV-1)-infected individuals is positively correlated with the level of integrated viral DNA in T cells. HTLV-1 replication is positively regulated by Tax and Rex and negatively regulated by the p30 and HBZ proteins. In the present study, we demonstrate that HTLV-1 encodes another negative regulator of virus expression, the p13 protein. Expressed separately, p13 localizes to the mitochondria, whereas in the presence of Tax, part of it is ...[more]