Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC3156285 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Yu Zhipeng Z Ho Lok Yin LY Wang Zhiyong Z Lin Qing Q
Bioorganic & medicinal chemistry letters 20110424 17
We report the discovery of two long-wavelength (365 nm) photoactivatable diaryltetrazoles through screening a small library of diaryltetrazoles that were designed using a 'scaffold hopping' strategy. A naphthalene-derived tetrazole showed excellent reactivity in the photoinduced cycloaddition reaction with methyl methacrylate under 365 nm photoirradiation in acetonitrile PBS buffer mixture. Besides, the brightly fluorescent pyrazoline cycloadducts that were formed further increase the potential ...[more]