Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC3328312 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Sun Hongmao H Tawa Gregory G Wallqvist Anders A
Drug discovery today 20111026 7-8
The general goal of drug discovery is to identify novel compounds that are active against a preselected biological target with acceptable pharmacological properties defined by marketed drugs. Scaffold hopping has been widely applied by medicinal chemists to discover equipotent compounds with novel backbones that have improved properties. In this article we classify scaffold hopping into four major categories, namely heterocycle replacements, ring opening or closure, peptidomimetics and topology- ...[more]