Ontology highlight
ABSTRACT:
SUBMITTER: Hua Z
PROVIDER: S-EPMC3156388 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Hua Zhengmao Z Lvov Anatoli A Morin Trevor J TJ Kobertz William R WR
Bioorganic & medicinal chemistry letters 20110428 17
Metabolic oligosaccharide engineering is a powerful approach for installing unnatural glycans with unique functional groups into the glycocalyx of living cells and animals. Using this approach, we showed that K(+) channel complexes decorated with thiol-containing sialic acids were irreversibly inhibited with scorpion toxins bearing a pendant maleimide group. Irreversible inhibition required a glycosylated K(+) channel subunit and was completely reversible with mild reductant when the tether conn ...[more]