Ontology highlight
ABSTRACT:
SUBMITTER: Kehl-Fie TE
PROVIDER: S-EPMC3157011 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Kehl-Fie Thomas E TE Chitayat Seth S Hood M Indriati MI Damo Steven S Restrepo Nicole N Garcia Carlos C Munro Kim A KA Chazin Walter J WJ Skaar Eric P EP
Cell host & microbe 20110801 2
By sequestering manganese and zinc, the neutrophil protein calprotectin plays a crucial role in host defense against bacterial and fungal pathogens. However, the essential processes disrupted by calprotectin remain unknown. We report that calprotectin enhances the sensitivity of Staphylococcus aureus to superoxide through inhibition of manganese-dependent bacterial superoxide defenses, thereby increasing superoxide levels within the bacterial cell. Superoxide dismutase activity is required for f ...[more]