Ontology highlight
ABSTRACT:
SUBMITTER: Huang SN
PROVIDER: S-EPMC3157054 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Huang Shar-yin N SN Pommier Yves Y Marchand Christophe C
Expert opinion on therapeutic patents 20110901 9
Inhibitors of topoisomerase I (Top1) that result in stalled Top1 cleavage complexes (Top1cc) are commonly employed against cancer. Combination chemotherapy with DNA repair inhibitors can potentially improve response to these widely used chemotherapeutics. One line of inquiry focuses on inhibitors of tyrosyl-DNA phosphodiesterase 1 (Tdp1), a repair enzyme for Top1cc. Tdp1 catalyzes the hydrolysis of DNA adducts covalently linked to the 3'-phosphate of DNA, including Top1-derived peptides and also ...[more]