Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TX
PROVIDER: S-EPMC3350798 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20120426 9
Substances with dual tyrosyl-DNA phosphodiesterase I-topoisomerase I inhibitory activity in one low molecular weight compound would constitute a unique class of anticancer agents that could potentially have significant advantages over drugs that work against the individual enzymes. The present study demonstrates the successful synthesis and evaluation of the first dual Top1-Tdp1 inhibitors, which are based on the indenoisoquinoline chemotype. One bis(indenoisoquinoline) had significant activity ...[more]