Ontology highlight
ABSTRACT:
SUBMITTER: Gurnev PA
PROVIDER: S-EPMC3157246 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Gurnev Philip A PA Rostovtseva Tatiana K TK Bezrukov Sergey M SM
FEBS letters 20110625 14
Recently reported functional interaction between voltage-dependent anion channel of the outer mitochondrial membrane, VDAC, and dimeric tubulin is observed as a reversible channel blockage. Using partitioning of poly-(ethylene glycol)s of different molecular weights and reversal potential measurements, we probe the size and ion selectivity of the fully open and tubulin-blocked states of VDAC reconstituted into planar lipid bilayers. While the effective radius of the channel decreases by only a f ...[more]