Ontology highlight
ABSTRACT:
SUBMITTER: Perry MW
PROVIDER: S-EPMC3158186 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Perry Michael W MW Boettiger Alistair N AN Levine Michael M
Proceedings of the National Academy of Sciences of the United States of America 20110808 33
Segmentation of the Drosophila embryo begins with the establishment of spatially restricted gap gene-expression patterns in response to broad gradients of maternal transcription factors, such as Bicoid. Numerous studies have documented the fidelity of these expression patterns, even when embryos are subjected to genetic or environmental stress, but the underlying mechanisms for this transcriptional precision are uncertain. Here we present evidence that every gap gene contains multiple enhancers ...[more]