Ontology highlight
ABSTRACT:
SUBMITTER: Reeves GT
PROVIDER: S-EPMC3469262 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Reeves Gregory T GT Trisnadi Nathanie N Truong Thai V TV Nahmad Marcos M Katz Sophie S Stathopoulos Angelike A
Developmental cell 20120216 3
Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy, we quantified the nuclear Dorsal gradient in space and time and found that its amplitude and basal levels display oscillations throughout early embryonic development. These dynamics raise questions regarding how cells can reproducibly establish patterns of gene expression from a rapidly varying signal. We theref ...[more]