Ontology highlight
ABSTRACT:
SUBMITTER: Rudd BD
PROVIDER: S-EPMC3158207 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Rudd Brian D BD Venturi Vanessa V Li Gang G Samadder Partha P Ertelt James M JM Way Sing Sing SS Davenport Miles P MP Nikolich-Žugich Janko J
Proceedings of the National Academy of Sciences of the United States of America 20110803 33
Immunity against new infections declines in the last quartile of life, as do numbers of naive T cells. Peripheral maintenance of naive T cells over the lifespan is necessary because their production drastically declines by puberty, a result of thymic involution. We report that this maintenance is not random in advanced aging. As numbers and diversity of naive CD8(+) T cells declined with aging, surviving cells underwent faster rates of homeostatic proliferation, were selected for high T-cell rec ...[more]