Ontology highlight
ABSTRACT:
SUBMITTER: Smithey MJ
PROVIDER: S-EPMC3504138 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Smithey Megan J MJ Li Gang G Venturi Vanessa V Davenport Miles P MP Nikolich-Žugich Janko J
Journal of immunology (Baltimore, Md. : 1950) 20121019 11
Persistent CMV infection has been associated with immune senescence. To address the causal impact of lifelong persistent viral infection on immune homeostasis and defense, we infected young mice systemically with HSV-1, murine CMV, or both viruses and studied their T cell homeostasis and function. Herpesvirus(+) mice exhibited increased all-cause mortality compared with controls. Upon Listeria-OVA infection, 23-mo-old animals that had experienced lifelong herpesvirus infections showed impaired b ...[more]