Ontology highlight
ABSTRACT:
SUBMITTER: Thomas SE
PROVIDER: S-EPMC3158865 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
World journal of diabetes 20110701 7
Both environmental and genetic factors contribute to the development of diabetes mellitus and although monogenic disorders are rare, they offer unique insights into the fundamental biology underlying the disease. Mutations of the insulin gene or genes involved in the response to protein misfolding cause early onset diabetes. These have revealed an important role for endoplasmic reticulum stress in β-cell survival. This form of cellular stress occurs when secretory proteins fail to fold efficient ...[more]