Ontology highlight
ABSTRACT:
SUBMITTER: Guo B
PROVIDER: S-EPMC3159455 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Guo Baoqiang B Panagiotaki Niki N Warwood Stacey S Sharrocks Andrew D AD
Nucleic acids research 20110504 15
Transcription factor activity is often controlled through the dynamic use of post-translational modifications. Two such modifications are acetylation and sumoylation, which both occur on lysine residues, providing the opportunity for cross-talk at the molecular level. Here, we focussed on the ETS-domain transcription factor PEA3 and studied the potential interplay between these two modifications. We demonstrate that PEA3 is acetylated in a p300-dependent manner. ERK MAPK pathway signalling poten ...[more]