Ontology highlight
ABSTRACT:
SUBMITTER: Rahman SH
PROVIDER: S-EPMC3159524 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Rahman Shamim H SH Maeder Morgan L ML Joung J Keith JK Cathomen Toni T
Human gene therapy 20110722 8
Zinc-finger nucleases (ZFNs) are a powerful tool that can be used to edit the human genome ad libitum. The technology has experienced remarkable development in the last few years with regard to both the target site specificity and the engineering platforms used to generate zinc-finger proteins. As a result, two phase I clinical trials aimed at knocking out the CCR5 receptor in T cells isolated from HIV patients to protect these lymphocytes from infection with the virus have been initiated. Moreo ...[more]