Ontology highlight
ABSTRACT:
SUBMITTER: Beumer KJ
PROVIDER: S-EPMC3789796 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Beumer Kelly J KJ Trautman Jonathan K JK Christian Michelle M Dahlem Timothy J TJ Lake Cathleen M CM Hawley R Scott RS Grunwald David J DJ Voytas Daniel F DF Carroll Dana D
G3 (Bethesda, Md.) 20131003 10
Zinc-finger nucleases have proven to be successful as reagents for targeted genome manipulation in Drosophila melanogaster and many other organisms. Their utility has been limited, however, by the significant failure rate of new designs, reflecting the complexity of DNA recognition by zinc fingers. Transcription activator-like effector (TALE) DNA-binding domains depend on a simple, one-module-to-one-base-pair recognition code, and they have been very productively incorporated into nucleases (TAL ...[more]