The activity of dispiro peroxides against Fasciola hepatica.

ABSTRACT: Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.

SUBMITTER: Wang X 

PROVIDER: S-EPMC3159854 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature