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The activity of dispiro peroxides against Fasciola hepatica.


ABSTRACT: Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.

SUBMITTER: Wang X 

PROVIDER: S-EPMC3159854 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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The activity of dispiro peroxides against Fasciola hepatica.

Wang Xiaofang X   Zhao Qingjie Q   Vargas Mireille M   Dong Yuxiang Y   Sriraghavan Kamaraj K   Keiser Jennifer J   Vennerstrom Jonathan L JL  

Bioorganic & medicinal chemistry letters 20110719 18


Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg. ...[more]

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