Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3159854 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20110719 18
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg. ...[more]