Dopaminergic network differences in human impulsivity.
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ABSTRACT:
SUBMITTER: Buckholtz JW
PROVIDER: S-EPMC3161413 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Dopaminergic network differences in human impulsivity.
Buckholtz Joshua W JW Treadway Michael T MT Cowan Ronald L RL Woodward Neil D ND Li Rui R Ansari M Sib MS Baldwin Ronald M RM Schwartzman Ashley N AN Shelby Evan S ES Smith Clarence E CE Kessler Robert M RM Zald David H DH
Science (New York, N.Y.) 20100701 5991
Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits remain largely unknown. By using a dual-scan positron emission tomography approach in healthy human volunteers with amphetamine and the D2/D3 ligand [18F]fallypride, we found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, w ...[more]
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