Ontology highlight
ABSTRACT:
SUBMITTER: Fang D
PROVIDER: S-EPMC5063542 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Fang Du D Qing Yu Y Yan Shijun S Chen Doris D Yan Shirley ShiDu SS
Stem cell reports 20160922 4
Mitochondria are critical to neurogenesis, but the mechanisms of mitochondria in neurogenesis have not been well explored. We fully characterized mitochondrial alterations and function in relation to the development of human induced pluripotent stem cell (hiPSC)-derived dopaminergic (DA) neurons. Following directed differentiation of hiPSCs to DA neurons, mitochondria in these neurons exhibit pronounced changes during differentiation, including mature neurophysiology characterization and functio ...[more]