Fine tuning by human CD1e of lipid-specific immune responses.
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ABSTRACT:
SUBMITTER: Facciotti F
PROVIDER: S-EPMC3161585 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Fine tuning by human CD1e of lipid-specific immune responses.
Facciotti Federica F Cavallari Marco M Angénieux Catherine C Garcia-Alles Luis F LF Signorino-Gelo François F Angman Lena L Gilleron Martine M Prandi Jacques J Puzo Germain G Panza Luigi L Xia Chengfeng C Wang Peng George PG Dellabona Paolo P Casorati Giulia G Porcelli Steven A SA de la Salle Henri H Mori Lucia L De Libero Gennaro G
Proceedings of the National Academy of Sciences of the United States of America 20110815 34
CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their tur ...[more]
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