Ontology highlight
ABSTRACT:
SUBMITTER: Hawkes M
PROVIDER: S-EPMC3162048 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Hawkes Michael M Opoka Robert Opika RO Namasopo Sophie S Miller Christopher C Conroy Andrea L AL Serghides Lena L Kim Hani H Thampi Nisha N Liles W Conrad WC John Chandy C CC Kain Kevin C KC
Medical hypotheses 20110713 3
We hypothesize that supplemental inhaled nitric oxide (iNO) will improve outcomes in children with severe malaria receiving standard antimalarial therapy. The rationale for the hypothesized efficacy of iNO rests on: (1) biological plausibility, based on known actions of NO in modulating endothelial activation; (2) pre-clinical efficacy data from animal models of experimental cerebral malaria; and (3) a human trial of the NO precursor l-arginine, which improved endothelial function in adults with ...[more]