Ontology highlight
ABSTRACT:
SUBMITTER: Plewes K
PROVIDER: S-EPMC6137116 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Plewes Katherine K Kingston Hugh W F HWF Ghose Aniruddha A Wattanakul Thanaporn T Hassan Md Mahtab Uddin MMU Haider Md Shafiul MS Dutta Prodip K PK Islam Md Akhterul MA Alam Shamsul S Jahangir Selim Md SM Zahed A S M ASM Sattar Md Abdus MA Chowdhury M A Hassan MAH Herdman M Trent MT Leopold Stije J SJ Ishioka Haruhiko H Piera Kim A KA Charunwatthana Prakaykaew P Silamut Kamolrat K Yeo Tsin W TW Lee Sue J SJ Mukaka Mavuto M Maude Richard J RJ Turner Gareth D H GDH Faiz Md Abul MA Tarning Joel J Oates John A JA Anstey Nicholas M NM White Nicholas J NJ Day Nicholas P J NPJ Hossain Md Amir MA Roberts Ii L Jackson LJ Dondorp Arjen M AM
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20180901 7
<h4>Background</h4>Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria.<h4>Methods</h4>This phase 2, open-label, randomized controlled trial conducted at two hospitals in Bangladesh assessed effects on renal function, safety, pharmacokinetic (PK) properties and pharmacodynamic (PD) effects of acetaminophen. Febrile patients (>12 years) with se ...[more]