APOE and Alzheimer disease: a major gene with semi-dominant inheritance.
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ABSTRACT:
SUBMITTER: Genin E
PROVIDER: S-EPMC3162068 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
APOE and Alzheimer disease: a major gene with semi-dominant inheritance.
Genin E E Hannequin D D Wallon D D Sleegers K K Hiltunen M M Combarros O O Bullido M J MJ Engelborghs S S De Deyn P P Berr C C Pasquier F F Dubois B B Tognoni G G Fiévet N N Brouwers N N Bettens K K Arosio B B Coto E E Del Zompo M M Mateo I I Epelbaum J J Frank-Garcia A A Helisalmi S S Porcellini E E Pilotto A A Forti P P Ferri R R Scarpini E E Siciliano G G Solfrizzi V V Sorbi S S Spalletta G G Valdivieso F F Vepsäläinen S S Alvarez V V Bosco P P Mancuso M M Panza F F Nacmias B B Bossù P P Hanon O O Piccardi P P Annoni G G Seripa D D Galimberti D D Licastro F F Soininen H H Dartigues J-F JF Kamboh M I MI Van Broeckhoven C C Lambert J C JC Amouyel P P Campion D D
Molecular psychiatry 20110510 9
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD LTR in 7351 cases and 10 132 controls from Caucasian ancestry using Rochester (USA) incidence data. At the age of 85 the LTR of AD without reference to APOE genotype was 11% in males and 14% in females. At the same age, this risk ranged from 51% for APOE44 male carriers to 60% for APOE44 female carrier ...[more]
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