Ontology highlight
ABSTRACT:
SUBMITTER: Murdock DG
PROVIDER: S-EPMC3861372 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20131212 12
Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study identify the KIAA1462 locus as a candidate locus for LOAD in APOE4 carriers. Two genes exist at this locus, ...[more]