Ontology highlight
ABSTRACT:
SUBMITTER: Zhang JS
PROVIDER: S-EPMC3162070 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Zhang J-S JS Koenig A A Harrison A A Ugolkov A V AV Fernandez-Zapico M E ME Couch F J FJ Billadeau D D DD
Oncogene 20110328 34
Glycogen synthase kinase-3 beta (GSK-3β) is overexpressed in a number of human malignancies and has been shown to contribute to tumor cell proliferation and survival. Although regulation of GSK-3β activity has been extensively studied, the mechanisms governing GSK-3β gene expression are still unknown. Using pancreatic cancer as a model, we find that constitutively active Ras signaling increases GSK-3β gene expression via the canonical mitogen-activated protein kinase signaling pathway. Analysis ...[more]