Ontology highlight
ABSTRACT:
SUBMITTER: Abe T
PROVIDER: S-EPMC3162410 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Abe Takuya T Sugimura Kazuto K Hosono Yoshifumi Y Takami Yasunari Y Akita Motomu M Yoshimura Akari A Tada Shusuke S Nakayama Tatsuo T Murofushi Hiromu H Okumura Katsuzumi K Takeda Shunichi S Horikoshi Masami M Seki Masayuki M Enomoto Takemi T
The Journal of biological chemistry 20110707 35
Ordered nucleosome disassembly and reassembly are required for eukaryotic DNA replication. The facilitates chromatin transcription (FACT) complex, a histone chaperone comprising Spt16 and SSRP1, is involved in DNA replication as well as transcription. FACT associates with the MCM helicase, which is involved in DNA replication initiation and elongation. Although the FACT-MCM complex is reported to regulate DNA replication initiation, its functional role in DNA replication elongation remains elusi ...[more]