Ontology highlight
ABSTRACT:
SUBMITTER: Kundu LR
PROVIDER: S-EPMC3428913 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Kundu Lena R LR Seki Masayuki M Watanabe Nanae N Murofushi Hiromu H Furukohri Asako A Waga Shou S Score Alan J AJ Blow J Julian JJ Horikoshi Masami M Enomoto Takemi T Tada Shusuke S
Biochimica et biophysica acta 20110111 6
The facilitates chromatin transcription (FACT) complex affects nuclear DNA transactions in a chromatin context. Though the involvement of FACT in eukaryotic DNA replication has been revealed, a clear understanding of its biochemical behavior during DNA replication still remains elusive. Here, we analyzed the chromatin-binding dynamics of FACT using Xenopus egg extract cell-free system. We found that FACT has at least two distinct chromatin-binding phases: (1) a rapid chromatin-binding phase at t ...[more]