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Cytokine gene polymorphism in idiopathic nephrotic syndrome children.


ABSTRACT: The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-? cytokines were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction and restriction fragment length polymorphism. On comparing patient with controls strong association were found for IL-6, TNF-? and IL-4 at allelic level (IL-6-G174C (G vs. C): P = <0.001; OR = 6.33, TNF-?-G308A (G vs. A): P = <0.001; OR = 1.99, IL-4-C590T (C vs. T): P = 0.048; OR = 1.38). Further when SR group was compared with SS group significant association was found at genotypic level in all the studied genetic polymorphisms. Studied cytokine gene polymorphisms may influence susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients.

SUBMITTER: Jafar T 

PROVIDER: S-EPMC3162962 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Cytokine gene polymorphism in idiopathic nephrotic syndrome children.

Jafar Tabrez T   Agrawal Suraksha S   Mahdi Abbas Ali AA   Sharma Raj Kumar RK   Awasthi Shally S   Agarwal G G GG  

Indian journal of clinical biochemistry : IJCB 20110407 3


The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-α cytokines were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction and restriction fragment length polymorphism. On comparing patient with controls strong association were found for  ...[more]

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