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Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates.

ABSTRACT: An efficient synthesis of spiro-fused macrolactams by a multicomponent macrocyclization reaction (MCMR) is reported. The use of highly reactive, transient intermediates in this MCMR permits short reaction times, even at high dilution. The methods employed for this MCMR were first developed as a four-component strategy for the synthesis of ?-ketoamide isoxazolines and a new macrocyclization reaction is reported.

SUBMITTER: Knapp JM

PROVIDER: S-EPMC3162989 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates.

Knapp John M JM Fettinger James C JC Kurth Mark J MJ

Organic letters 20110809 17

An efficient synthesis of spiro-fused macrolactams by a multicomponent macrocyclization reaction (MCMR) is reported. The use of highly reactive, transient intermediates in this MCMR permits short reaction times, even at high dilution. The methods employed for this MCMR were first developed as a four-component strategy for the synthesis of β-ketoamide isoxazolines and a new macrocyclization reaction is reported. ...[more]

PMID: 21827181

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