Ontology highlight
ABSTRACT:
SUBMITTER: Trzoss L
PROVIDER: S-EPMC3163030 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Organic letters 20110803 17
The first enantioselective synthesis of (-)-jiadifenin (1), a potent neurite outgrowth promoter isolated from the Illicium species, is described. The synthetic strategy builds upon bicyclic motif 6, which represents the AB ring of the natural product and proceeds in 19 steps and 1.1% overall yield. Key to our approach is a Mn(III)-mediated oxidation reaction of A ring that, following a regio- and diastereoselective α-hydroxylation and methylation sequence, produces the desired functionalities of ...[more]