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Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation.

ABSTRACT: Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.

SUBMITTER: Chang A

PROVIDER: S-EPMC3163058 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation.

Chang Aram A Singh Shanteri S Phillips George N GN Thorson Jon S JS

Current opinion in biotechnology 20110516 6

Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of the ...[more]

PMID: 21592771

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