Ontology highlight
ABSTRACT:
SUBMITTER: Sun F
PROVIDER: S-EPMC3163066 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Chemistry & biology 20110801 8
Increasing antibiotic resistance in human pathogens necessitates the development of new approaches against infections. Targeting virulence regulation at the transcriptional level represents a promising strategy yet to be explored. A global transcriptional regulator, MgrA in Staphylococcus aureus, was identified previously as a key virulence determinant. We have performed a fluorescence anisotropy (FA)-based high-throughput screen that identified 5, 5-methylenedisalicylic acid (MDSA), which block ...[more]