Ontology highlight
ABSTRACT:
SUBMITTER: Koch G
PROVIDER: S-EPMC5536197 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cell chemical biology 20170629 7
Scaffold proteins are ubiquitous chaperones that bind proteins and facilitate physical interaction of multi-enzyme complexes. Here we used a biochemical approach to dissect the scaffold activity of the flotillin-homolog protein FloA of the multi-drug-resistant human pathogen Staphylococcus aureus. We show that FloA promotes oligomerization of membrane protein complexes, such as the membrane-associated RNase Rny, which forms part of the RNA-degradation machinery called the degradosome. Cells lack ...[more]