Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.
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ABSTRACT:
SUBMITTER: Roy S
PROVIDER: S-EPMC3163151 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
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Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.
Roy Subhadeep S Zanotti Kimberly J KJ Murphy Connor T CT Tanious Farial A FA Wilson W David WD Ly Danith H DH Armitage Bruce A BA
Chemical communications (Cambridge, England) 20110630 30
Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies. ...[more]
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