Ontology highlight
ABSTRACT:
SUBMITTER: Shao H
PROVIDER: S-EPMC3163732 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Shao Hanjuan H Chaerkady Raghothama R Chen Shoujun S Pinto Sneha M SM Sharma Rakesh R Delanghe Bernard B Birk David E DE Pandey Akhilesh A Chakravarti Shukti S
Journal of proteomics 20110517 10
To elucidate how the deficiency of a major corneal proteoglycan, lumican, affects corneal homeostasis, we used mass spectrometry to derive the proteome profile of the lumican-deficient and the heterozygous mouse corneas and compared these to the wild type corneal proteome. 2108 proteins were quantified in the mouse cornea. Selected proteins and transcripts were investigated by Western blot and quantitative RT-PCR, respectively. We observed major changes in the composition of the stromal extracel ...[more]