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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.

ABSTRACT: Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

SUBMITTER: Li M

PROVIDER: S-EPMC3163746 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.

Li Meng M Zhao Hong H Zhang Xiaosong X Wood Laura D LD Anders Robert A RA Choti Michael A MA Pawlik Timothy M TM Daniel Hubert D HD Kannangai Rajesh R Offerhaus G Johan A GJ Velculescu Victor E VE Wang Linfang L Zhou Shibin S Vogelstein Bert B Hruban Ralph H RH Papadopoulos Nick N Cai Jianqiang J Torbenson Michael S MS Kinzler Kenneth W KW

Nature genetics 20110807 9

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting tha ...[more]

PMID: 21822264

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