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MiR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGF?1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment.

SUBMITTER: Yu P

PROVIDER: S-EPMC7094640 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression.

Yu Peng P Wu Dingguo D You Yu Y Sun Jing J Lu Lele L Tan Jiaxing J Bie Ping P

Experimental cell research 20150710 2

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test r ...[more]

PMID: 26169693

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