Ontology highlight
ABSTRACT:
SUBMITTER: Ginsberg SD
PROVIDER: S-EPMC3163754 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Ginsberg Stephen D SD Mufson Elliott J EJ Alldred Melissa J MJ Counts Scott E SE Wuu Joanne J Nixon Ralph A RA Che Shaoli S
Journal of chemical neuroanatomy 20110612 2
Endocytic system dysfunction is one of the earliest disturbances that occur in Alzheimer's disease (AD), and may underlie the selective vulnerability of cholinergic basal forebrain (CBF) neurons during the progression of dementia. Herein we report that genes regulating early and late endosomes are selectively upregulated within CBF neurons in mild cognitive impairment (MCI) and AD. Specifically, upregulation of rab4, rab5, rab7, and rab27 was observed in CBF neurons microdissected from postmorte ...[more]