Ontology highlight
ABSTRACT:
SUBMITTER: Mukherji S
PROVIDER: S-EPMC3163764 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Mukherji Shankar S Ebert Margaret S MS Zheng Grace X Y GX Tsang John S JS Sharp Phillip A PA van Oudenaarden Alexander A
Nature genetics 20110821 9
MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target gene's protein expression in the presence and absence of regulation by miRNA. We find that although the average level of repression is modest, in agreement with previous population-based measurements, the repression among individual cells varies dr ...[more]