Ontology highlight
ABSTRACT:
SUBMITTER: Blevins R
PROVIDER: S-EPMC4340958 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Blevins Rory R Bruno Ludovica L Carroll Thomas T Elliott James J Marcais Antoine A Loh Christina C Hertweck Arnulf A Krek Azra A Rajewsky Nikolaus N Chen Chang-Zheng CZ Fisher Amanda G AG Merkenschlager Matthias M
PLoS genetics 20150225 2
The development and homeostasis of multicellular organisms relies on gene regulation within individual constituent cells. Gene regulatory circuits that increase the robustness of gene expression frequently incorporate microRNAs as post-transcriptional regulators. Computational approaches, synthetic gene circuits and observations in model organisms predict that the co-regulation of microRNAs and their target mRNAs can reduce cell-to-cell variability in the expression of target genes. However, whe ...[more]