Ontology highlight
ABSTRACT:
SUBMITTER: Neely GG
PROVIDER: S-EPMC3164203 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Neely G Gregory GG Keene Alex C AC Duchek Peter P Chang Elaine C EC Wang Qiao-Ping QP Aksoy Yagiz Alp YA Rosenzweig Mark M Costigan Michael M Woolf Clifford J CJ Garrity Paul A PA Penninger Josef M JM
PloS one 20110831 8
Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage the systems that detect noxious stimuli are therefore under strict evolutionary pressure. We developed a high-throughput behavioral method to identify genes contributing to thermal nociception in the fruit fly and have reported a large-scale screen th ...[more]