Unknown

Dataset Information

0

The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.


ABSTRACT: Thermotaxis is important for animal survival, but the molecular identities of temperature sensors controlling this behavior have not been determined. We demonstrate dTRPA1, a heat-activated Transient Receptor Potential (TRP) family ion channel, is essential for thermotaxis in Drosophila. dTrpA1 knockdown eliminates avoidance of elevated temperatures along a thermal gradient. We observe dTRPA1 expression in cells without previously ascribed roles in thermosensation and implicate dTRPA1-expressing neurons in mediating thermotaxis. Our data suggest that thermotaxis relies upon neurons and molecules distinct from those required for high-temperature nociception. We propose dTRPA1 may control thermotaxis by sensing environmental temperature.

SUBMITTER: Rosenzweig M 

PROVIDER: S-EPMC548941 | biostudies-other | 2005 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC3164203 | biostudies-literature
| S-EPMC2746756 | biostudies-literature
| S-EPMC5122779 | biostudies-literature
| S-EPMC3281117 | biostudies-literature
| S-EPMC3013099 | biostudies-literature
| S-EPMC4249797 | biostudies-literature
| S-EPMC5882232 | biostudies-literature
| S-EPMC8011302 | biostudies-literature
| S-EPMC3892162 | biostudies-literature
| S-EPMC6938258 | biostudies-literature