Ontology highlight
ABSTRACT:
SUBMITTER: Tse YC
PROVIDER: S-EPMC3164463 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Tse Yu Chung YC Piekny Alisa A Glotzer Michael M
Molecular biology of the cell 20110707 17
Assembly of a cytokinetic contractile ring is a form of cell polarization in which the equatorial cell cortex becomes differentiated from the polar regions. Microtubules direct cytokinetic polarization via the central spindle and astral microtubules. The mechanism of central spindle-directed furrow formation is reasonably well understood, but the aster-directed pathway is not. In aster-directed furrowing, cytoskeletal factors accumulate to high levels at sites distal to the asters and at reduced ...[more]