Ontology highlight
ABSTRACT:
SUBMITTER: Lanasa MC
PROVIDER: S-EPMC3164475 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Lanasa M C MC Allgood S D SD Slager S L SL Dave S S SS Love C C Marti G E GE Kay N E NE Hanson C A CA Rabe K G KG Achenbach S J SJ Goldin L R LR Camp N J NJ Goodman B K BK Vachon C M CM Spector L G LG Rassenti L Z LZ Leis J F JF Gockerman J P JP Strom S S SS Call T G TG Glenn M M Cerhan J R JR Levesque M C MC Weinberg J B JB Caporaso N E NE
Leukemia 20110527 9
Monoclonal B-cell lymphocytosis (MBL) is a hematologic condition wherein small B-cell clones can be detected in the blood of asymptomatic individuals. Most MBL have an immunophenotype similar to chronic lymphocytic leukemia (CLL), and 'CLL-like' MBL is a precursor to CLL. We used flow cytometry to identify MBL from unaffected members of CLL kindreds. We identified 101 MBL cases from 622 study subjects; of these, 82 individuals with MBL were further characterized. In all, 91 unique MBL clones wer ...[more]