Ontology highlight
ABSTRACT:
SUBMITTER: Matsuoka RL
PROVIDER: S-EPMC3164552 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Neuron 20110801 3
In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal lamination. However, the mechanisms by which retinal neurites are segregated within the inner or outer plexiform layers are not known. We find that the transmembrane semaphorins Sema5A and Sema5B constrain neurites from multiple retinal neuron subtypes within the inner plexiform layer (IPL). In Sema5A⁻/⁻; Sema5B⁻/⁻ mice, retinal ganglion cells (R ...[more]