Ontology highlight
ABSTRACT:
SUBMITTER: Adikesavan AK
PROVIDER: S-EPMC3164682 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Adikesavan Anbu K AK Katsonis Panagiotis P Marciano David C DC Lua Rhonald R Herman Christophe C Lichtarge Olivier O
PLoS genetics 20110901 9
RecA plays a key role in homologous recombination, the induction of the DNA damage response through LexA cleavage and the activity of error-prone polymerase in Escherichia coli. RecA interacts with multiple partners to achieve this pleiotropic role, but the structural location and sequence determinants involved in these multiple interactions remain mostly unknown. Here, in a first application to prokaryotes, Evolutionary Trace (ET) analysis identifies clusters of evolutionarily important surface ...[more]