Ontology highlight
ABSTRACT:
SUBMITTER: Kovacic L
PROVIDER: S-EPMC3834820 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Kovačič Lidija L Paulič Nejc N Leonardi Adrijana A Hodnik Vesna V Anderluh Gregor G Podlesek Zdravko Z Žgur-Bertok Darja D Križaj Igor I Butala Matej M
Nucleic acids research 20130821 21
RecA protein is a hallmark for the bacterial response to insults inflicted on DNA. It catalyzes the strand exchange step of homologous recombination and stimulates self-inactivation of the LexA transcriptional repressor. Importantly, by these activities, RecA contributes to the antibiotic resistance of bacteria. An original way to decrease the acquisition of antibiotic resistance would be to block RecA association with LexA. To engineer inhibitors of LexA-RecA complex formation, we have mapped t ...[more]