Ontology highlight
ABSTRACT:
SUBMITTER: Helmus JJ
PROVIDER: S-EPMC3164902 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Helmus Jonathan J JJ Surewicz Krystyna K Apostol Marcin I MI Surewicz Witold K WK Jaroniec Christopher P CP
Journal of the American Chemical Society 20110815 35
The Y145Stop mutant of human prion protein, huPrP23-144, has been linked to PrP cerebral amyloid angiopathy, an inherited amyloid disease, and also serves as a valuable in vitro model for investigating the molecular basis of amyloid strains. Prior studies of huPrP23-144 amyloid by magic-angle-spinning (MAS) solid-state NMR spectroscopy revealed a compact β-rich amyloid core region near the C-terminus and an unstructured N-terminal domain. Here, with the focus on understanding the higher-order ar ...[more]