Ontology highlight
ABSTRACT:
SUBMITTER: Shannon MD
PROVIDER: S-EPMC6342661 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Shannon Matthew D MD Theint Theint T Mukhopadhyay Dwaipayan D Surewicz Krystyna K Surewicz Witold K WK Marion Dominique D Schanda Paul P Jaroniec Christopher P CP
Chemphyschem : a European journal of chemical physics and physical chemistry 20181107 2
Microsecond to millisecond timescale backbone dynamics of the amyloid core residues in Y145Stop human prion protein (PrP) fibrils were investigated by using <sup>15</sup> N rotating frame (R<sub>1ρ</sub> ) relaxation dispersion solid-state nuclear magnetic resonance spectroscopy over a wide range of spin-lock fields. Numerical simulations enabled the experimental relaxation dispersion profiles for most of the fibril core residues to be modelled by using a two-state exchange process with a common ...[more]