Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers.
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ABSTRACT:
SUBMITTER: Chinh NT
PROVIDER: S-EPMC3165334 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers.
Chinh Nguyen Trong NT Quang Nguyen Ngoc NN Anh Chu Xuan CX Thanh Nguyen Xuan NX Dai Bui B Birrell Geoffrey W GW Chavchich Marina M Edstein Michael D MD
Antimicrobial agents and chemotherapy 20110705 9
In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate and its major active metabolite, dihydroartemisinin, are responsible for most of the ex vivo antimalarial activity, with a delayed contribution by azithromycin. ...[more]
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